Published Articles

February 15, 2025

Nitrogen dioxide sterilization of a set of five ophthalmic active pharmaceutical ingredients: Impact on impurity profile and content

Literature about sterilization of pharmaceutical substances is limited. The aim of this study was to evaluate the effect of nitrogen dioxide (NO2) sterilization, a new emerging technology, on five different ophthalmic active pharmaceutical ingredients...

January 24, 2025

Darlington Nuclear’s Newly Refurbished Unit 1 now Producing life-saving Cobalt-60 Isotopes

The recently refurbished Unit 1 reactor at OPG’s Darlington Nuclear Generating Station is now producing critical life-saving Cobalt-60 isotopes for the world...

October 19, 2024

Nitrogen Dioxide

Final sterilization of your pre-filled injection device may be required, especially if it contains an integrated fluid path or is used in specific indications like ophthalmic...

September 3, 2024

Selecting the Right Sterilization Technology

Published: Oliver Healthcare Packaging

As part of PackTalk’s month-long focus on sterilization, we recently sat down with Sterigenics, a global leader in comprehensive sterilization solutions, to better understand...

April 5, 2023

Sterilization of biopharmaceuticals: Effect of gamma irradiation, e-beam irradiation and Nitrogen dioxide on human insulin

Published: The International Journal of Pharmaceutics

Biopharmaceuticals are administered parenterally and therefore sterility is required. Sterility can be obtained via different processes including exposure to steam or dry heat...

January 6, 2023

Sterilization of Micronized Indomethacin

Published: Frontiers in Analytical Science

Sterilization is a pivotal topic in the pharmaceutical industry, whereby the nomenclature of “sterile” refers to the absence of viable microorganisms. Since microorganisms can reproduce in the body and...

January 28, 2022

The effect of Gamma and Ethylene Oxide Sterilization on a Selection of Active Pharmaceutical Ingredients for Ophthalmics

Published: Journal of Pharmaceutical Sciences

Ensuring the sterility of life science products plays a pivotal role in the healthcare sector. Gamma irradiation and ethylene...

December 13, 2021

The Cobalt-60 Pioneers

Published: The Medicine Maker

Cobalt-60 is widely used in the medical device space for terminal sterilization, but how is it used in the pharma industry...

June 10, 2021

Biological safety in the context of backward planetary protection and Mars Sample Return: conclusions from the Sterilization Working Group

Published: Cambridge University Press

The National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA) are studying how samples might be brought back to Earth from Mars safely. Backward planetary protection is key in this complex endeavour, as it is required to prevent potential adverse effects from returning materials to Earth’s biosphere....

January 17, 2018

Gamma Irradiation of Animal Serum: Maintaining the Cold Chain Throughout the Process